Trends in Antibacterial Resistance Among Streptococcus pneumoniae in the USA
Author Information
Author(s): Stephen G. Jenkins, Steven D. Brown, David J. Farrell
Primary Institution: Mount Sinai Medical Center, Mount Sinai School of Medicine, New York, NY, USA
Hypothesis
What are the trends in antibacterial resistance of Streptococcus pneumoniae isolates in the USA over four years?
Conclusion
Resistance to penicillin and erythromycin among pneumococcal isolates has remained high, but the prevalence of multidrug-resistant strains is increasing.
Supporting Evidence
- Over 39,000 S. pneumoniae isolates were collected during the study.
- Resistance rates for penicillin and erythromycin remained high at 21.2% and 29.3%, respectively.
- Multidrug resistance among isolates remained stable at approximately 30% over the study period.
- Telithromycin and levofloxacin showed high in vitro activity against S. pneumoniae isolates.
Takeaway
This study looked at how many germs that cause pneumonia are resistant to antibiotics over four years, and found that many still are, which is a big problem for doctors trying to help sick people.
Methodology
The study used a longitudinal surveillance approach to collect and analyze S. pneumoniae isolates from patients with respiratory infections, determining their susceptibility to various antibiotics.
Potential Biases
Potential bias may arise from the selection of collection centers and the exclusion of certain patient populations.
Limitations
The study may not fully represent all geographic regions or patient demographics due to varying sample sizes and collection methods.
Participant Demographics
Isolates were collected from both pediatric and adult patients, with a majority aged 15-64 years, and approximately 50% were hospitalized.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website