Synthesis of methylenebisamides using CC- or DCMT-activated DMSO
2008
Synthesis of Methylenebisamides Using DMSO
publication
Evidence: moderate
Author Information
Author(s): Wang Qiang, Sun Lili, Jiang Yu, Li Chunbao
Primary Institution: Tianjin University
Hypothesis
The study investigates the use of new electrophiles to activate DMSO for the synthesis of methylenebisamides from amides.
Conclusion
The developed method allows for the efficient production of methylenebisamides with good yields using CC- or DCMT-activated DMSO.
Supporting Evidence
- The study found that using CC or DCMT as activators improved the yields of methylenebisamides.
- The method is operationally simple and uses inexpensive reagents.
- The reaction conditions were optimized for various substrates to enhance yields.
Takeaway
This study shows a new way to make a special type of chemical compound called methylenebisamides using simple and cheap ingredients.
Methodology
The reactions of amides with DMSO activated by CC or DCMT were optimized for various substrates to produce methylenebisamides.
Limitations
The method was not efficient for aliphatic amides, which produced considerable by-products.
Digital Object Identifier (DOI)
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