TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6
2011
TDP-43 Knockdown Affects Neurite Growth
publication
Evidence: moderate
Author Information
Author(s): Fiesel Fabienne C, Schurr Christine, Weber Stephanie S, Kahle Philipp J
Primary Institution: Hertie Institute for Clinical Brain Research, University of Tuebingen
Hypothesis
Does TDP-43 knockdown impair neurite outgrowth through its target HDAC6?
Conclusion
TDP-43 deficiency leads to impairment of neurite growth in an HDAC6-dependent manner.
Supporting Evidence
- TDP-43 knockdown significantly impairs neurite outgrowth.
- Re-transfection with TDP-43 and HDAC6 rescues neurite outgrowth.
- Silencing HDAC6 alone reduces neurite outgrowth.
Takeaway
When a protein called TDP-43 is reduced, it makes nerve cells grow less, which can be bad for brain health.
Methodology
The study used human neuroblastoma SH-SY5Y cells to assess neurite outgrowth after silencing TDP-43 and HDAC6.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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