Fate of biomedical research protocols and publication bias in France: retrospective cohort study
2006

Impact of Funding on Biomedical Research

Sample size: 142 publication Evidence: moderate

Author Information

Author(s): Evelyne Decullier, François Chapuis

Primary Institution: Clinical Epidemiology Unit; DIM-Hospices Civils de Lyon, Lyon, France

Hypothesis

Absence of acknowledged funding does not hamper implementation nor publication.

Conclusion

Some protocols submitted for funding were initiated and completed without any funding declared.

Supporting Evidence

  • 38% of studies were funded by the Greater Lyon research committee.
  • 100% initiation rate for studies with both committee and external funding.
  • 62% completion rate for studies with at least one funding.
  • 77% publication rate for studies with either committee or external funding.

Takeaway

The study looked at research projects to see if they started and finished even without funding, and found that many did.

Methodology

Retrospective cohort study of protocols submitted for funding to the Greater Lyon regional scientific committee in 1997.

Potential Biases

There was a tendency for publication bias and oral presentation bias.

Limitations

The study was based on only one regional scientific committee.

Participant Demographics

Protocols were primarily conducted in France, with a mix of human and non-human studies.

Statistical Information

P-Value

0.001

Confidence Interval

95% CI: 0.37–6.71

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1186/1471-2458-6-165

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