Histone Lactylation in Macrophages and Its Role in Disease
Author Information
Author(s): Bao Chuncha, Ma Qing, Ying Xihong, Wang Fengsheng, Hou Yue, Wang Dun, Zhu Linsen, Huang Jiapeng, He Chengqi
Primary Institution: West China Hospital, Sichuan University
Hypothesis
Histone lactylation is a key epigenetic modification that influences macrophage plasticity and disease progression.
Conclusion
Histone lactylation plays a significant role in regulating macrophage functions and has therapeutic implications in various diseases.
Supporting Evidence
- Histone lactylation is linked to macrophage activation and polarization.
- Alterations in histone lactylation levels can influence disease mechanisms.
- Targeting histone lactylation may provide new therapeutic strategies for various diseases.
Takeaway
Histone lactylation is like a special tag that helps macrophages change how they work in response to different situations, which can affect diseases.
Methodology
This review synthesizes recent research on histone lactylation's effects on macrophage activation and its implications in various diseases.
Limitations
The review highlights gaps in understanding the complete enzymatic machinery involved in histone lactylation and its interactions with other modifications.
Digital Object Identifier (DOI)
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