The Complexity of Antibody-Dependent Enhancement of Dengue Virus Infection
2010
Understanding Antibody-Dependent Enhancement in Dengue Virus Infection
Commentary
Evidence: moderate
Author Information
Author(s): Guzman Maria G., Vazquez Susana
Primary Institution: Department of Virology, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, “Pedro Kouri” Tropical Medicine Institute of Havana, Cuba
Hypothesis
Antibody-dependent enhancement (ADE) is a mechanism that may explain the severity of dengue hemorrhagic fever during secondary infections.
Conclusion
Secondary dengue infections can lead to more severe disease due to the mechanism of antibody-dependent enhancement.
Supporting Evidence
- Secondary infections of dengue are associated with a higher risk of severe disease.
- Antibody-dependent enhancement can lead to increased viral load and severity of dengue.
- Maternal antibodies can influence the severity of dengue in infants.
Takeaway
When someone gets dengue for the second time, their body's antibodies can sometimes make the illness worse instead of better.
Digital Object Identifier (DOI)
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