Magnesium for Neuroprotection in Birth Asphyxia
Author Information
Author(s): Gathwala Geeta, Khera Atul, Singh Jagjit, Balhara Bharti
Primary Institution: Pt. B.D. Sharma Post Graduate Institute of Medical Sciences, University of Health Sciences, Rohtak, Haryana, India
Hypothesis
The study evaluated the neuroprotective role of magnesium in birth asphyxia.
Conclusion
Magnesium is well tolerated and does appear to have beneficial effects in babies with severe asphyxia.
Supporting Evidence
- EEG abnormalities occurred in 43.75% of the control group compared to 31.25% in the study group.
- CT scan abnormalities were present in 62.5% of the control group compared to 37.5% in the study group.
- At 6 months, more babies in the control group were either abnormal or suspect compared to the study group.
Takeaway
This study looked at whether giving magnesium to babies who had trouble breathing at birth could help protect their brains. It seems like magnesium might help a little bit.
Methodology
Forty term neonates with severe birth asphyxia were randomized to receive magnesium sulfate or standard care, followed by assessments using CT, EEG, and Denver II.
Limitations
The study had a small sample size and a short follow-up period.
Participant Demographics
Term neonates with severe birth asphyxia, appropriate for gestational age.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website