Thymidine Phosphorylase and Chemotherapy in Gastric Cancer
Author Information
Author(s): Saito H, Tsujitani S, Oka S, Kondo A, Ikeguchi M, Maeta M, Kaibara N
Primary Institution: First Department of Surgery, Tottori University School of Medicine
Hypothesis
The expression of thymidine phosphorylase correlates with angiogenesis and the efficacy of chemotherapy using fluorouracil derivatives in advanced gastric carcinoma.
Conclusion
Patients with thymidine phosphorylase-positive tumors have a better prognosis when treated with fluorouracil derivatives compared to those who are not treated.
Supporting Evidence
- The expression of thymidine phosphorylase was negative in 72 cases and positive in 54.
- Microvessel density correlated with the expression of thymidine phosphorylase.
- Patients with TP-positive tumors survived longer than those with TP-negative tumors.
- In patients treated with fluorouracil derivatives, TP expression significantly correlated with a favorable prognosis.
- In patients with TP-positive tumors, treatment with fluorouracil derivatives led to significantly better outcomes.
Takeaway
This study found that a protein called thymidine phosphorylase can help doctors understand how well chemotherapy will work for patients with stomach cancer.
Methodology
Immunohistochemistry was used to examine the expression of thymidine phosphorylase and microvessel density in advanced gastric carcinoma.
Participant Demographics
Patients with advanced gastric carcinoma.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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