Squamous cell carcinoma antigen suppresses radiation-induced cell death
2001
SCCA and Radiation-Induced Cell Death
publication
Author Information
Author(s): Murakami A, Suminami Y, Hirakawa H, Nawata S, Numa F, Kato H
Primary Institution: Yamaguchi University School of Medicine
Hypothesis
Does SCCA2, similar to SCCA1, suppress radiation-induced apoptosis?
Conclusion
Both SCCA1 and SCCA2 help squamous cells survive radiation-induced cell death by regulating the p38 MAPK pathway.
Supporting Evidence
- SCCA1 and SCCA2 were shown to suppress cell death induced by radiation treatment.
- Caspase 3 activity and activated caspase 9 expression were reduced in SCCA-transfected cells after radiation.
- Phosphorylated p38 MAPK levels were lower in SCCA-transfected cells compared to control cells.
Takeaway
SCCA proteins help protect cells from dying when they are exposed to radiation.
Methodology
The study examined the effects of SCCA1 and SCCA2 on radiation-induced apoptosis in transfected cells.
Digital Object Identifier (DOI)
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