Case of Sinusoidal Obstruction Syndrome in Colon Cancer Patient
Author Information
Author(s): Agarwal Vijay, Sgouros Joseph, Smithson Jacqueline, Lodge JPA, Razack Abdul, Campbell Anne, Maraveyas Anthony
Primary Institution: Princess Royal Hospital, Hull, UK
Hypothesis
Can bevacizumab cause sinusoidal obstruction syndrome (veno-occlusive disease) in patients with metastatic colorectal cancer?
Conclusion
Bevacizumab can cause sinusoidal obstruction syndrome, and ascites should not be assumed to be due to disease progression without proper evaluation.
Supporting Evidence
- The patient developed sinusoidal obstruction syndrome after receiving bevacizumab.
- Liver biopsy showed features consistent with sinusoidal obstruction syndrome.
- The patient recovered after stopping bevacizumab and adopting a watchful waiting approach.
Takeaway
A patient with colon cancer developed liver problems after taking a cancer drug called bevacizumab, showing that this drug can cause serious side effects.
Methodology
Case report detailing the patient's treatment and subsequent health issues.
Limitations
Only one case is reported, limiting generalizability.
Participant Demographics
77-year-old man with metastatic colon cancer.
Digital Object Identifier (DOI)
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