How Mechanical Forces Affect PIEZO1 in Obesity and Diabetes
Author Information
Author(s): Victoria Catalán, Javier Gómez-Ambrosi, Beatriz Ramírez, Xabier Unamuno, Sara Becerril, Amaia Rodríguez, Jorge Baixauli, Gabriel Reina, Ana Sancho, Camilo Silva, Javier A. Cienfuegos, Gema Frühbeck
Primary Institution: Clínica Universidad de Navarra, Pamplona, Spain
Hypothesis
PIEZO1 is dysregulated in visceral adipose tissue in the context of obesity and obesity-associated type 2 diabetes, being activated by mechanical forces and influencing the development of adipose tissue inflammation.
Conclusion
Obesity and type 2 diabetes increase PIEZO1 expression in visceral adipose tissue, which is linked to inflammation and mechanical forces.
Supporting Evidence
- PIEZO1 expression levels were significantly associated with key inflammatory markers in visceral adipose tissue.
- Static compression of VAT explants promoted an upregulation of PIEZO1 and inflammatory mediators.
- Adipocyte secretome from patients with obesity increased PIEZO1 levels in macrophages.
Takeaway
This study found that being overweight makes a specific protein, PIEZO1, more active in fat tissue, which can lead to inflammation and other health problems.
Methodology
Blood and visceral adipose tissue samples were collected from 100 volunteers, and static compression studies were performed on VAT explants to assess PIEZO1 response.
Participant Demographics
59 females and 41 males, including normoglycemic patients with normal weight and individuals diagnosed with obesity.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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