Genetic polymorphisms of N-acetyltransferase 1 and 2 and risk of cigarette smoking-related bladder cancer
1999
Genetic Factors and Bladder Cancer Risk from Smoking
Sample size: 258
publication
Evidence: moderate
Author Information
Author(s): Hsieh F-I, Pu Y-S, Chern H-D, Hsu L-I, Chiou H-Y, Chen C-J
Primary Institution: National Taiwan University
Hypothesis
This study examined the association of N-acetyltransferases (NAT) 1 and 2 genotypes with the risk of smoking-related bladder cancer.
Conclusion
The study found that certain genetic variants may increase the risk of bladder cancer in smokers.
Supporting Evidence
- A total of 74 pathologically confirmed bladder cancer patients and 184 controls were recruited.
- There was a significant dose–response relationship between the risk of bladder cancer and the quantity and duration of cigarette smoking.
- The biological gradients were significant among subjects carrying NAT1*10 allele or NAT2 slow acetylators.
Takeaway
Some people have genes that make them more likely to get bladder cancer if they smoke cigarettes.
Methodology
The study involved genotyping NAT1 and NAT2 in bladder cancer patients and controls, along with a questionnaire on smoking history.
Participant Demographics
74 bladder cancer patients and 184 controls from Taiwan.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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