Intraventricular Dyssynchrony in Light Chain Amyloidosis
Author Information
Author(s): Raymond Q Migrino, Leanne Harmann, Timothy Woods, Megan Bright, Seth Truran, Parameswaran Hari
Primary Institution: Medical College of Wisconsin
Hypothesis
Light chain amyloidosis is associated with regional systolic dyssynchrony.
Conclusion
Light chain amyloidosis is associated with left ventricular regional systolic dyssynchrony.
Supporting Evidence
- AL subjects had significantly higher 16-SD% compared to healthy controls.
- Left ventricular ejection fraction was comparable between groups.
- 16-SD% correlated with left ventricular mass index.
Takeaway
People with a rare disease called light chain amyloidosis have problems with how their heart beats in different parts, even if their overall heart function seems okay.
Methodology
The study used 3D echocardiography to compare left ventricular regional synchrony in 10 AL subjects and 10 healthy controls.
Limitations
The sample size is small, limiting the ability to generalize findings.
Participant Demographics
10 biopsy-proven AL subjects (60 ± 3 years, 5 females) and 10 healthy controls (52 ± 1 years, 5 females).
Statistical Information
P-Value
0.003
Statistical Significance
p = 0.003
Digital Object Identifier (DOI)
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