Effects of Adding a Second Diabetes Drug After Metformin Fails
Author Information
Author(s): Jermendy György, Erdesz Diana, Nagy Laszlo, Yin Don, Phatak Hemant, Karve Sudeep, Engel Samuel, Balkrishnan Rajesh
Primary Institution: Bajcsy-Zsilinszly Hospital
Hypothesis
What is the status of glycemic control and patient-reported outcomes in Hungarian patients with type 2 diabetes who were prescribed additional medications after metformin monotherapy failure?
Conclusion
Nearly 75% of patients were not at A1C goal of < 6.5% despite using two oral anti-hyperglycemic medications.
Supporting Evidence
- Approximately 75% of patients were not at glycemic goal after the addition of sulfonylurea or thiazolidinedione to their metformin monotherapy.
- Patients not at glycemic goal reported being less likely to take medications exactly as prescribed.
- Self-reported hypoglycemia was negatively associated with health-related quality of life.
Takeaway
Most people with diabetes in this study didn't get their blood sugar under control even after taking extra medicine. Some even had low blood sugar that made them feel sick.
Methodology
This observational study assessed glycemic control and patient-reported outcomes in type 2 diabetes patients who added a sulfonylurea or thiazolidinedione to metformin therapy.
Potential Biases
Potential bias due to self-reported data and observational design.
Limitations
The study was observational and cannot infer causality; detailed reasons for medication changes were not collected.
Participant Demographics
Mean age of participants was 60.5 years, with 49.8% female.
Statistical Information
P-Value
0.017
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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