Study of Pharmaceutical Tablet Formulations Using Fibre Optic Probes
Author Information
Author(s): Remoto Peter J. G., Gordon Keith C., Fraser-Miller Sara J.
Primary Institution: University of Otago
Hypothesis
Can custom-designed fibre optic probes effectively analyze pharmaceutical tablet formulations using Raman and near-infrared spectroscopy?
Conclusion
The study demonstrated that different probe configurations could reliably collect data and showed robust quantitative performances.
Supporting Evidence
- Probe A effectively estimated hydroxymethyl cellulose and lactose monohydrate content using near-infrared spectroscopy.
- Probe B was most effective for estimating titanium dioxide content using a combination of Raman and near-infrared spectroscopy.
- Indomethacin content was best estimated using a low-level fused dataset collected with spatially offset Raman spectroscopy.
Takeaway
Researchers created special tools to look inside medicine tablets without breaking them, helping to understand their ingredients better.
Methodology
The study used Raman and near-infrared spectroscopy to analyze pharmaceutical tablets, employing principal component analysis and partial least squares regression for data evaluation.
Limitations
The effectiveness of the probes varied with different materials, and some configurations were less effective in quantifying certain components.
Digital Object Identifier (DOI)
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