Genetic Variants in the Mu Opioid Receptor and Alcohol Responses in American Indians
Author Information
Author(s): Ehlers Cindy L, Lind Penelope A, Wilhelmsen Kirk C
Primary Institution: The Scripps Research Institute
Hypothesis
The study investigates the association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians.
Conclusion
The minor allele for most polymorphisms in the OPRM1 receptor gene was associated with a more intense and/or adverse response to alcohol, which correlates with lower alcohol consumption and reduced susceptibility to dependence.
Supporting Evidence
- The study found that endorsing a more intense response to alcohol was significantly associated with having at least one minor allele for 7 SNPs in the OPRM1 gene.
- Heritability estimates for the subjective high assessment scale (SHAS-E) phenotypes ranged from 0.01 to 0.28.
- 64% of participants had a lifetime diagnosis of alcohol dependence.
Takeaway
Some people have genes that make them feel alcohol effects differently, and this study found that certain gene variations in American Indians are linked to feeling more intense effects from drinking.
Methodology
Participants provided blood samples and completed a structured interview; their responses to alcohol were measured using the subjective high assessment scale (SHAS-E).
Potential Biases
Potential biases may arise from the self-reported nature of alcohol responses and the specific demographic of the sample.
Limitations
The findings may not generalize to other Native Americans, and the study's reliance on self-reported data could introduce bias.
Participant Demographics
Participants were American Indians of mixed heritage, aged 18 to 70, with a mean age of 30.2 years, including 110 males and 141 females.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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