Effects of Verapamil, Nicardipine, and Nitroglycerin on Heart Injury
Author Information
Author(s): Hitoshi Yui, Uno Beppu, Hisashi Ito, Mitsuhiro Furuya, Hirofumi Arisaka, Kazu-Ichi Yoshida
Primary Institution: Kanagawa Dental College
Hypothesis
Do verapamil, nicardipine, and nitroglycerin have infarct size-limiting and antiarrhythmic effects in rabbit hearts during ischemia/reperfusion?
Conclusion
Verapamil and nitroglycerin significantly reduced myocardial infarct size and the incidence and duration of arrhythmias during ischemia and reperfusion in rabbits.
Supporting Evidence
- Verapamil and nitroglycerin reduced infarct size significantly compared to the control group.
- Incidence of arrhythmias during ischemia was 0% in the verapamil and nitroglycerin groups.
- Duration of arrhythmias was significantly lower in the verapamil and nitroglycerin groups compared to the control.
Takeaway
This study found that two heart medications, verapamil and nitroglycerin, help protect the heart from damage when blood flow is cut off and then restored, while another medication, nicardipine, did not work as well.
Methodology
Rabbits were subjected to 30 minutes of ischemia followed by 3 hours of reperfusion, with treatments administered prior to ischemia.
Limitations
Rabbits that experienced lethal arrhythmias were excluded from the analysis.
Participant Demographics
Male New Zealand White rabbits weighing 2.7–3.2 kg.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website