Loss of functional pRB is not a ubiquitous feature of B-cell malignancies
1999
Functional Status of pRB in B-cell Malignancies
Sample size: 11
publication
Evidence: moderate
Author Information
Author(s): Sinclair A J, Frost V
Primary Institution: School of Biological Sciences, University of Sussex
Hypothesis
Is the loss of functional pRB a common feature in B-cell malignancies?
Conclusion
The study found that pRB is functional in certain B-cell lines, contrary to the belief that its loss is ubiquitous in B-cell malignancies.
Supporting Evidence
- The study identified eleven B-cell lines expressing hyperphosphorylated pRB.
- pRB was found to be functional in these B-cell lines.
Takeaway
The study looked at some cancer cells and found that a protein called pRB is still working in them, which is surprising because people thought it was usually broken.
Methodology
Examined the functional status of pRB in a panel of human B-cell lines.
Digital Object Identifier (DOI)
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