Chemical Stability of New Acyclovir Analogues
Author Information
Author(s): Hristov Georgi Stankova, Ivanka Stankova
Primary Institution: South-West University ‘Neofit Rilski’
Hypothesis
The study aims to assess the chemical stability of synthesised acyclovir esters with peptidomimetics at different pH levels.
Conclusion
The acyclovir esters were unstable in acidic media but showed varying stability at neutral pH, with Boc-2-Val-thiazole-acyclovir being the most stable.
Supporting Evidence
- The study found that some acyclovir esters were unstable under acidic conditions.
- Boc-2-Val-thiazole-acyclovir showed the highest stability at pH 7.4 compared to other compounds.
- The stability of the compounds was assessed using half-lives calculated from hydrolysis rates.
Takeaway
The researchers looked at how stable new versions of a medicine called acyclovir are in different conditions, finding that some break down quickly in acid but are more stable in neutral conditions.
Methodology
The stability of acyclovir esters was studied using HPLC at pH 1.0 and pH 7.4 at 37°C.
Limitations
The compounds were not stable in acidic media, which limits their effectiveness in such environments.
Digital Object Identifier (DOI)
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