Incidence of Progressive Childhood Encephalopathy in Oslo
Author Information
Author(s): Petter Stromme, Oivind Kanavin, Michael Abdelnoor, Berit Woldseth, Terje Rootwelt, Jorgen Diderichsen, Bjorn Bjurulf, Finn Sommer, Per Magnus
Primary Institution: Ullevål University Hospital and Faculty of Medicine, University of Oslo, Norway
Hypothesis
What is the incidence rate and aetiology of progressive encephalopathy in children in Oslo?
Conclusion
The overall incidence rate of progressive encephalopathy was found to be 6.43 per 100,000 person years, with a significant reduction in incidence rates as age increased.
Supporting Evidence
- The incidence rate of progressive encephalopathy was 6.43 per 100,000 person years.
- 66% of the cases were metabolic disorders.
- 71% of cases presented before the age of 1 year.
- The study included 84 cases among 1,305,997 person years.
Takeaway
This study looked at how many kids in Oslo get a brain disease called progressive encephalopathy, and they found that younger kids are more likely to have it.
Methodology
The study included cases of progressive encephalopathy born between 1985 and 2003 in Oslo, tracking new cases from 1985 to 2004 and calculating incidence rates based on person-years at risk.
Potential Biases
There may be risks of bias due to incomplete data from earlier years and reliance on diagnostic coding.
Limitations
The study may have missed some cases due to reliance on medical records and the potential underestimation of cases in the last years of the observation period.
Participant Demographics
The study included children born between 1985 and 2003, with a male to female ratio of approximately 2:1.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 5.15–7.97
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website