Impact of uPAR Levels in Breast Cancer
Author Information
Author(s): Witte J H de, Foekens J A, Brünner N, Heuvel J J T M, Tienoven ThH van, Look M P, Klijn J G M, Geurts-Moespot A, Grebenchtchikov N, Benraad ThJ, Sweep C G J
Primary Institution: Department of Chemical Endocrinology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
Hypothesis
High levels of urokinase-type plasminogen activator receptor (uPAR) in breast tumors are associated with poor patient survival.
Conclusion
High levels of uPAR in cytosols are linked to reduced overall survival in breast cancer patients.
Supporting Evidence
- uPAR levels in pellet extracts were more than 3-fold higher than in cytosols.
- High cytosolic uPAR levels were significantly associated with reduced overall survival.
- uPAR levels in pellet extracts were not related to patient survival.
- Elevated uPAR levels were independent predictors of poor overall survival.
Takeaway
This study found that higher amounts of a specific protein in breast cancer tumors can mean that patients might not live as long.
Methodology
The study used an enzyme-linked immunosorbent assay (ELISA) to measure uPAR levels in tumor samples.
Statistical Information
P-Value
P< 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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