Using Fenoldopam to Control Blood Pressure in Children
Author Information
Author(s): Gregory B Hammer, Susan T Verghese, David R Drover, Myron Yaster, Joseph R Tobin
Primary Institution: Stanford University School of Medicine
Hypothesis
What are the pharmacokinetic and pharmacodynamic characteristics of fenoldopam in pediatric patients?
Conclusion
Fenoldopam is effective for controlling blood pressure in children during surgery, with a higher effective dose range than in adults.
Supporting Evidence
- Fenoldopam at doses of 0.8 and 3.2 mcg/kg/min significantly reduced blood pressure.
- The effective dose range for children is 0.8–1.2 mcg/kg/min.
- Side effects were minimal and occurred in a minority of patients.
Takeaway
Fenoldopam helps lower blood pressure in kids during surgery, and they need a higher dose than adults to get the same effect.
Methodology
A randomized, multicenter, placebo-controlled trial with 77 children aged 3 weeks to 12 years undergoing surgery.
Limitations
The anesthetic technique varied, newborns and older adolescents were excluded, and the study did not assess long-term effects.
Participant Demographics
Majority were males (56%) and Caucasians (65%), mean age was 51.9 months.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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