Vascular endothelial growth factor-C expression in human prostatic carcinoma and its relationship to lymph node metastasis
1999
VEGF-C and Prostate Cancer Spread
publication
Evidence: moderate
Author Information
Author(s): Tsurusaki T, Kanda S, Sakai H, Kanetake H, Saito Y, Alitalo K, Koji T
Primary Institution: Nagasaki University School of Medicine
Hypothesis
Does the expression of VEGF-C in prostatic carcinoma relate to lymph node metastasis?
Conclusion
Higher levels of VEGF-C in prostatic carcinoma are associated with lymph node metastasis.
Supporting Evidence
- VEGF-C mRNA levels were significantly higher in lymph node-positive prostatic carcinoma.
- The number of VEGFR-3-positive vessels increased around VEGF-C-positive prostatic carcinoma cells.
Takeaway
This study found that a substance called VEGF-C in prostate cancer cells might help the cancer spread to lymph nodes.
Methodology
In situ hybridization and immunohistochemical staining were used to investigate VEGF-C and VEGFR-3 expression.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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