SDF-1α and CXCR4 in Colorectal Cancer
Author Information
Author(s): Yoshitake N, Fukui H, Yamagishi H, Sekikawa A, Fujii S, Tomita S, Ichikawa K, Imura J, Hiraishi H, Fujimori T
Primary Institution: Dokkyo University School of Medicine
Hypothesis
The expression of SDF-1α and CXCR4 is associated with lymph node metastasis in colorectal cancer.
Conclusion
The expression of SDF-1α and nuclear CXCR4 predicts lymph node metastasis in colorectal cancers.
Supporting Evidence
- Stromal cell-derived factor-1α and CXCR4 expression were significantly associated with lymph node metastasis.
- Patients with nuclear CXCR4 expression showed more frequent lymph node metastasis.
- Most colorectal cancer patients with lymph node metastases showed strong SDF-1α expression.
Takeaway
This study found that certain proteins in colorectal cancer can help predict if the cancer will spread to nearby lymph nodes.
Methodology
Immunohistochemical analysis of SDF-1α and CXCR4 expression in colorectal cancer tissues and related lymph nodes.
Limitations
The study excluded patients with certain conditions and those who received preoperative treatments.
Participant Demographics
{"gender":{"men":41,"women":19},"age":{"mean":63.8,"range":"39-88"}}
Statistical Information
P-Value
0.002
Confidence Interval
95% CI 1.08–6.41
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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