Effects of Blood Pressure Changes on Brain NIRS Measurements
Author Information
Author(s): Minati Ludovico, Kress Inge U., Visani Elisa, Medford Nick, Critchley Hugo D.
Primary Institution: Brighton & Sussex Medical School
Hypothesis
Can transient blood pressure changes confound brain near-infrared spectroscopy (NIRS) measurements?
Conclusion
Blood pressure fluctuations can significantly affect brain NIRS measurements, indicating the need for continuous monitoring during such studies.
Supporting Evidence
- Transient blood pressure changes were induced by arm-raising.
- Blood pressure changes significantly altered deep and shallow NIRS recordings.
- The effect appears to originate from both intra- and extra-cranial regions.
- Blood pressure must be considered as a potential confound in NIRS studies.
Takeaway
When you raise your arm, your blood pressure goes up, and this can mess with brain scans that use light to see how your brain is working.
Methodology
Participants underwent visual stimulation while their blood pressure was manipulated by arm-raising, with NIRS recordings taken from the occipital cortex.
Potential Biases
Potential bias due to the small number of participants and the assumption of wavepath and penetration depth.
Limitations
The study had a small sample size and could not confirm whether the effects were solely extra-cranial or included intra-cranial influences.
Participant Demographics
16 participants (9 female, 7 male), aged 25 ± 7 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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