Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas
1999
Role of Gelatinases in Gliomas
Sample size: 46
publication
Evidence: moderate
Author Information
Author(s): Forsyth P A, Wong H, Laing T D, Rewcastle N B, Morris D G, Muzik H, Leco K J, Johnston R N, Brasher P M A, Sutherland G, Edwards D R
Primary Institution: Tom Baker Cancer Centre
Hypothesis
Deregulated expression of gelatinase-A or B, or an activator of gelatinase-A, MT1-MMP, may contribute directly to human gliomas.
Conclusion
Gelatinase-A, -B, and MT1-MMP are important in the pathophysiology of human gliomas.
Supporting Evidence
- Gelatinase-A levels were higher in glioma specimens compared to normal tissue.
- Gelatinase-B transcript and activity levels were higher than in normal brain and correlated with tumor grade.
- MT1-MMP expression did not closely relate to activated gelatinase-A levels.
- Gelatinase-A and MT1-MMP were localized to malignant glioma cells and blood vessels.
Takeaway
This study found that certain proteins called gelatinases are involved in brain tumors, helping them grow and spread.
Methodology
Quantified the expression of MMPs in brain tumor specimens and control tissues using quantitative RT-PCR and gelatin zymography.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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