Activated mesothelial cells produce heparin-binding growth factors: implications for tumour metastases
2000
How mesothelial cells contribute to tumor spread
publication
Author Information
Author(s): Jayne D G, Perry S L, Morrison E, Farmery S M, Guillou P J
Primary Institution: Surgical Unit, Level 8, Clinical Sciences Building, St James's University Hospital, Leeds, UK
Hypothesis
Do activated mesothelial cells produce heparin-binding growth factors that influence tumor metastases?
Conclusion
The study found that activated mesothelial cells produce growth factors that may contribute to tumor recurrence after surgery.
Supporting Evidence
- Peritoneal mesothelial cells express mRNA for several growth factors.
- Cytokines can up-regulate the expression of certain growth factors in mesothelial cells.
- The production of heparin-binding growth factors may influence tumor recurrence.
Takeaway
This study shows that certain cells in the abdomen can make substances that help tumors grow back after surgery.
Methodology
The study analyzed mRNA expression and protein levels of growth factors in mesothelial cells after cytokine stimulation.
Digital Object Identifier (DOI)
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