Genetic Diversity of Plasmodium vivax in India
Author Information
Author(s): Prajapati Surendra K, Verma Anju, Adak Tridibes, Yadav Rajpal S, Kumar Ashwini, Eapen Alex, Das Manoj K, Singh Neeru, Sharma Surya K, Rizvi Moshahid A, Dash Aditya P, Joshi Hema
Primary Institution: National Institute of Malaria Research (ICMR)
Hypothesis
What is the extent of diversity in Pvgam-1 among field isolates of Plasmodium vivax in India?
Conclusion
The study shows limited diversity of the Pvgam-1 marker in Indian isolates with a well representation of both Belem and Chesson type alleles.
Supporting Evidence
- Both Belem and Chesson type alleles were present among isolates from all study sites.
- The Belem type allele was predominant, occurring in 67% of isolates.
- The proportion of isolates showing mixed forms of alleles was about 13% overall.
Takeaway
Scientists studied blood samples from people in India to see how different the malaria parasite is. They found two main types of the parasite, but not a lot of variety.
Methodology
The study used nested PCR assays to assess the diversity of Pvgam-1 among field isolates collected from different regions of India.
Limitations
The study could not correlate molecular markers with clinical findings.
Participant Demographics
Field isolates were collected from 10 different geographical regions in India, including urban and rural settings.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website