ETK/BMX and Bladder Cancer Prognosis
Author Information
Author(s): Guo Shengjie, Sun Feng, Guo Zhiyong, Li Wei, Alfano Alan, Chen Hegang, Magyar Clara E., Huang Jiaoti, Chai Toby C., Qiu Shaopeng, Qiu Yun
Primary Institution: University of Maryland School of Medicine
Hypothesis
ETK expression is progressively increased during bladder cancer progression and predicts poor prognosis.
Conclusion
ETK is significantly upregulated in bladder cancer and its expression level predicts the survival rate of patients with cystectomy.
Supporting Evidence
- ETK expression is progressively increased during bladder cancer progression.
- Down-regulation of ETK in bladder cancer cells attenuated STAT3 and AKT activity.
- ETK expression level predicts the survival rate of patients with cystectomy.
Takeaway
This study found that a protein called ETK is higher in bladder cancer and can help doctors know which patients might not do well.
Methodology
The study involved immunohistochemistry analysis on tissue microarrays containing 619 human bladder tissue samples.
Limitations
The study is limited to the analysis of ETK expression in bladder cancer and does not explore other potential biomarkers.
Participant Demographics
The study included 233 patients with bladder cancer.
Statistical Information
P-Value
0.0028
Confidence Interval
95% CI: 1.1 to 2.7
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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