Study on 5HT1b Receptor Gene and Methamphetamine Dependence

Sample size: 479 publication Evidence: low

Author Information

Author(s): Ujike H, Kishimoto M, Okahisa Y, Kodama M, Takaki M, Inada T, Uchimura N, Yamada M, Iwata N, Iyo M, Sora I, Ozaki N

Primary Institution: Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Is there a genetic association between the 5HT1b receptor gene and methamphetamine dependence in a Japanese population?

The study found no significant association between the 5HT1b receptor gene and methamphetamine dependence or related clinical phenotypes.

The study involved 231 patients with methamphetamine dependence and 248 healthy controls.
No significant differences were found in the genotype or allele frequencies of the SNPs between the groups.
Haplotype analysis showed no significant differences in haplotype distribution between methamphetamine dependence and controls.

The researchers looked at a gene to see if it affects how people get addicted to methamphetamine, but they found it doesn't really matter.

A case-control genetic association study was conducted with 231 patients and 248 healthy controls, genotyping three SNPs of the HTR1B gene.

The study only examined three specific SNPs and did not consider other potential polymorphisms in the HTR1B gene.

231 patients (184 male, 47 female; mean age 36.6) and 248 healthy controls (198 male, 50 female; mean age 36.6).

p=0.37 for rs6297, p=0.30 for rs130058, p=0.14 for rs1228814

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