Vascular Grading of Angiogenesis in Breast Cancer
Author Information
Author(s): Hansen S, Grabau D A, Sørensen F B, Bak M, Vach W, Rose C
Primary Institution: Odense University Hospital
Hypothesis
The study aimed to evaluate the prognostic value of angiogenesis by vascular grading of primary breast tumours.
Conclusion
The study concluded that angiogenesis determined by vascular grading has independent prognostic value for patients with breast cancer.
Supporting Evidence
- Vascular grade was significantly associated with axillary node involvement, tumour size, malignancy grade, oestrogen receptor status, and histological type.
- Vascular grade significantly predicted recurrence free survival and overall survival for all patients.
- Cox multivariate regression analysis showed that vascular grading contributed independent prognostic value.
Takeaway
This study looked at how blood vessel growth in breast tumors can help predict how well patients will do. It found that grading this growth can give important information about a patient's prognosis.
Methodology
The microvessels were immunohistochemically stained and graded semiquantitatively into three groups based on the number of microvessels.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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