Fluoxetine Reduces Neurogenesis in Mice
Author Information
Author(s): Ohira Koji, Miyakawa Tsuyoshi
Primary Institution: Fujita Health University
Hypothesis
Does long-term treatment with fluoxetine affect neurogenesis in the subventricular zone of adult mice?
Conclusion
Long-term treatment with fluoxetine decreases neurogenesis in the subventricular zone while increasing it in the dentate gyrus.
Supporting Evidence
- Fluoxetine treatment increased cell proliferation in the dentate gyrus.
- Fluoxetine treatment decreased cell proliferation in the subventricular zone after 6 and 9 weeks.
- The study suggests that decreased neurogenesis in the SVZ may relate to side effects of antidepressants.
Takeaway
Giving mice fluoxetine for a long time helps grow new brain cells in one part of the brain but stops them from growing in another part.
Methodology
Adult male C57BL/6J mice were treated with fluoxetine for up to 9 weeks, and neurogenesis was assessed using BrdU labeling and immunohistochemistry.
Limitations
The study was conducted on mice, and results may not directly translate to humans.
Participant Demographics
Adult male C57BL/6J mice, 8 weeks old at the start of the experiments.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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