Anti-Her-2/neu Antibody and Breast Cancer Cells
Author Information
Author(s): Brodowicz T, Kandioler D, Tomek S, Ludwig C, Rudas M, Kunstfeld R, Koestler W, Hejna M, Budinsky A, Wiltschke C, Zielinski C C
Primary Institution: University Hospital, Ludwig Boltzmann Institute for Clinical Experimental Oncology, Vienna, Austria
Hypothesis
Does anti-Her-2/neu antibody induce apoptosis in breast cancer cells regardless of p53 status?
Conclusion
The study found that anti-Her-2/neu antibody induces apoptosis in breast cancer cells independently of p53 status.
Supporting Evidence
- All seven tested breast cancer cell lines exhibited apoptosis when treated with anti-Her-2/neu antibody.
- The apoptosis was independent of the p53 and bcl-2 status of the cells.
- Anti-Her-2/neu antibody did not induce apoptosis in HER-2/neu negative cell lines.
Takeaway
This study shows that a specific antibody can make breast cancer cells die, no matter if they have a working p53 gene or not.
Methodology
The effect of anti-Her-2/neu antibody on apoptosis was investigated in various breast cancer cell lines with different p53 and bcl-2 statuses.
Digital Object Identifier (DOI)
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