Gene Rearrangement in Thyroid Cancers Related to Chernobyl
Author Information
Author(s): Santoro M, Thomas G A, Vecchio G, Williams G H, Fusco A, Chiappetta G, Pozcharskaya V, Bogdanova T I, Demidchik E P, Cherstvoy E D, Voscoboinik L, Tronko N D, Carss A, Bunnell H, Tonnachera M, Parma J, Dumont J E, Keller G, Höfler H, Williams E D
Primary Institution: Centro di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Biologia e Patologia Cellulare, e Moleculare, Universita di Napoli, Italy
Hypothesis
The study aims to link morphology with molecular biology in thyroid cancers post-Chernobyl.
Conclusion
Rearrangements of the RET oncogene were found in 44% of papillary carcinomas studied, with specific rearrangements associated with different variants of the cancer.
Supporting Evidence
- 44% of papillary carcinomas showed rearrangements of the RET oncogene.
- Rearrangements were linked to specific variants of papillary carcinoma.
Takeaway
The study looked at thyroid cancer in kids after Chernobyl and found that a specific gene change happens in many of these cancers.
Methodology
Examined 106 papillary carcinomas from children under 15 for RET oncogene rearrangements using RT-PCR.
Participant Demographics
Children under 15 years old from areas exposed to Chernobyl fallout.
Digital Object Identifier (DOI)
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