Link between HDL cholesterol and chromosome 2 in women
Author Information
Author(s): Kari E North, Lisa J Martin, Tom Dyer, Anthony G Comuzzie, Jeff T Williams
Primary Institution: Department of Epidemiology, University of North Carolina, Chapel Hill
Hypothesis
Does aging influence the ability to detect linkage of HDL-C in the Framingham Heart Study?
Conclusion
The study found evidence for a QTL on chromosome 2q influencing HDL-C variation in women, but not in men.
Supporting Evidence
- The study examined HDL-C levels at three time points spaced approximately 8 years apart.
- A maximum LOD score of 3.4 was obtained on chromosome 2 for the first observation.
- The genetic correlations of HDL-C between time points were highly correlated for both sexes.
Takeaway
The study looked at how HDL cholesterol levels are linked to genetics in women, finding a specific area on chromosome 2 that affects these levels.
Methodology
The study used a longitudinal sample from the Framingham Heart Study, analyzing HDL-C levels at three time points and performing linkage analysis.
Limitations
The study lacked complete covariate data to evaluate other potential influences on HDL-C variation.
Participant Demographics
Participants included both males and females from the Framingham Heart Study, with a mean age of 38.3, 46.5, and 54.8 years at the three time points.
Statistical Information
P-Value
0.01
Statistical Significance
p = 0.01
Digital Object Identifier (DOI)
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