GlyNAC and Aging in Mouse Hearts
Author Information
Author(s): Cieslik Katarzyna, Angellini Aude, Marquez Grecia Garcia, Fiorotto Marta, Taffet George
Primary Institution: Houston Methodist Hospital, BCM
Hypothesis
Does GlyNAC supplementation improve cardiac function in aging mice differently based on sex?
Conclusion
GlyNAC supplementation improves cardiac diastolic function in aging male mice but has a much smaller effect in females.
Supporting Evidence
- GlyNAC improved cardiac diastolic function in aging male mice.
- A smaller effect of GlyNAC was observed in female mice.
- GlyNAC increased expression of Ndufb8, a mitochondrial respiratory chain complex subunit.
- Higher enzymatic activities for CPT1b and CrAT were noted with GlyNAC supplementation.
- No significant change in fibrillar collagen was detected in GlyNAC-fed old males.
Takeaway
Giving older male mice a special diet can help their hearts work better, but it doesn't help female mice as much.
Methodology
The study involved supplementing a diet with GSH precursors (GlyNAC) for 3 months and measuring cardiac function and exercise performance in 21-month-old male and female mice.
Limitations
The study primarily focused on male mice, with limited effects observed in females.
Participant Demographics
21-month-old male and female mice.
Digital Object Identifier (DOI)
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