N-(2-Hydroxy-5-nitrophenyl)methanesulfonamide ethanol monosolvate
2011
Study of N-(2-Hydroxy-5-nitrophenyl)methanesulfonamide Ethanol Monosolvate
publication
Evidence: moderate
Author Information
Author(s): Li Hong-Ming, Cai Zhi-Qiang, Li Yi-Liang, Zhang Shi-Yu
Primary Institution: Tianjin Key Lab of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research
Hypothesis
The title compound is an important intermediate in the preparation of nimesulide derivatives.
Conclusion
The study reports the synthesis and crystal structure of the title compound, which is involved in hydrogen bonding interactions.
Supporting Evidence
- The compound is an intermediate in the preparation of nimesulide derivatives.
- The ethanol molecule is involved in hydrogen bonding to sulfonamide molecules.
- The study provides detailed crystallographic information.
Takeaway
This study looks at a chemical compound that helps make a medicine for breast cancer, showing how it is structured and how it interacts with other molecules.
Methodology
The compound was synthesized using a series of chemical reactions and characterized using X-ray diffraction.
Digital Object Identifier (DOI)
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