Determining Creatinine in Urine Using Continuous-Flow Analysis
Author Information
Author(s): Lourival C. de Faria, Celio Pasquini
Primary Institution: Instituto de Quimica, Universidade Estadual de Campinas
Hypothesis
The monosegmented continuous-flow system (MCFS) can effectively determine creatinine levels in urine.
Conclusion
The MCFS method for creatinine determination is comparable in accuracy to standard methods while allowing for higher sample throughput.
Supporting Evidence
- The MCFS allows for 130 determinations per hour with a relative standard deviation of less than 1.5%.
- The results from the MCFS method agreed with those obtained by standard manual and automated methods.
- The correlation coefficient between the MCFS and Cobas-Mira results was 0.9980.
Takeaway
This study shows a new way to test for creatinine in urine that is faster and just as accurate as older methods.
Methodology
The study used a monosegmented continuous-flow system to analyze urine samples for creatinine concentration.
Limitations
The study does not address potential interferences from other substances in urine.
Participant Demographics
Urine samples were supplied by the State University of Campinas's hospital.
Statistical Information
Statistical Significance
p<0.05
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