Dimeric and polymeric IgA, but not monomeric IgA, enhance the production of IL-6 by human renal mesangial cells
1996
IgA and IL-6 Production in Human Mesangial Cells
publication
Evidence: moderate
Author Information
Author(s): T. J. F. Reterink, W. E. M. Schroeijers, L. A. van Es, M. R. Daha
Primary Institution: Leiden University Hospital
Hypothesis
The size of IgA affects its capability to enhance IL-6 production in human mesangial cells.
Conclusion
Dimeric and polymeric IgA significantly enhance IL-6 production in human mesangial cells, while monomeric IgA does not.
Supporting Evidence
- Dimeric IgA increased IL-6 production by 3-fold, while polymeric IgA increased it by 9-fold.
- Monomeric IgA did not induce a significant increase in IL-6 production.
- IL-6 production was inhibited by cycloheximide, indicating de novo synthesis.
Takeaway
This study found that certain types of IgA can make kidney cells produce a substance called IL-6, which is important for inflammation.
Methodology
Human mesangial cells were cultured and stimulated with different forms of IgA to measure IL-6 production.
Participant Demographics
Human fetal kidneys were used to obtain mesangial cells.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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