Creatine Supplementation and Plasma Lipid Profile in Sedentary Males
Author Information
Author(s): Gualano Bruno, Ugrinowitsch Carlos, Artioli Guilherme G, Benatti Fabiana B, Scagliusi Fernanda B, Harris Roger C, Lancha Antonio H Junior
Primary Institution: University of São Paulo, Brazil
Hypothesis
Does creatine supplementation improve the plasma lipid profile in healthy male subjects undergoing aerobic training?
Conclusion
Creatine supplementation does not provide any additional benefits to the plasma lipid profile beyond those achieved through aerobic training alone.
Supporting Evidence
- Creatine supplementation did not show significant changes in fasting insulin or glycemia.
- Both groups showed improvements in HDL and reductions in TAG and VLDL after aerobic training.
- No significant differences were found between the creatine and placebo groups in lipid profiles.
Takeaway
This study looked at whether taking creatine helps improve cholesterol levels while exercising. It found that creatine didn't make a difference compared to just exercising.
Methodology
A double-blind, randomized, placebo-controlled trial with 22 sedentary males undergoing aerobic training for 12 weeks, comparing creatine supplementation to a placebo.
Potential Biases
Potential bias in self-reported dietary intake and participant blinding.
Limitations
The study only included healthy sedentary males, which may limit the generalizability of the findings to other populations.
Participant Demographics
Sedentary males aged 18-35 years, without pre-existing renal or cardiovascular diseases.
Statistical Information
P-Value
0.01 for HDL, 0.02 for TAG, 0.01 for VLDL
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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