Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway
2008
Necrotic Neurons Increase Microglial Toxicity
publication
Evidence: moderate
Author Information
Author(s): Teresa F. Pais, Catarina Figueiredo, Rui Peixoto, Maria H. Braz, Sukalyan Chatterjee
Primary Institution: Instituto Gulbenkian de Ciência
Hypothesis
Necrotic neurons activate microglia through a MyD88-dependent pathway, leading to increased neurotoxicity.
Conclusion
Necrotic neurons activate microglia via a MyD88-dependent pathway, resulting in increased neurotoxic activity through glutaminase induction.
Supporting Evidence
- Necrotic neurons induced a pro-inflammatory phenotype in microglia.
- Microglial activation was dependent on the MyD88 signaling pathway.
- Increased neurotoxicity was linked to up-regulation of glutaminase.
Takeaway
When brain cells die, they can make other brain cells act in a harmful way, which can make things worse for the brain.
Methodology
Primary cultures of microglia were used to study the effects of necrotic neurons on microglial inflammatory responses and toxicity.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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