Study of Hepatitis C Virus Genotype 2b and Treatment Response
Author Information
Author(s): Kadokura Makoto, Maekawa Shinya, Sueki Ryota, Miura Mika, Komase Kazuki, Shindo Hiroko, Amemiya Fumitake, Uetake Tomoyoshi, Inoue Taisuke, Sakamoto Minoru, Nakagawa Mina, Sakamoto Naoya, Watanabe Mamoru, Enomoto Nobuyuki
Primary Institution: University of Yamanashi, Tokyo Medical and Dental University
Hypothesis
The study investigates the correlation between viral sequence variation in genotype 2b hepatitis C virus and the response to peginterferon and ribavirin therapy.
Conclusion
Viral sequences are more diverse in patients who achieve a sustained virological response compared to those who do not.
Supporting Evidence
- 87.5% of non-SVR patients were relapsers.
- SVR patients had a higher diversity in viral sequences.
- Specific regions in the viral genome were associated with treatment outcomes.
Takeaway
This study found that patients with a certain type of hepatitis C virus had more varied virus sequences if their treatment worked well.
Methodology
The study analyzed the complete open reading frame sequences of genotype 2b HCV from 60 patients to assess their correlation with treatment outcomes.
Limitations
The study had a small sample size and did not include IL28B SNP analysis.
Participant Demographics
Adult Japanese patients infected with genotype 2b HCV.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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