TIMP-1 enhancer sequence – real or bacterial?
2003
Concerns About TIMP-1 Enhancer Sequence
Commentary
Author Information
Author(s): I M Clark, D A Young, D R Edwards
Primary Institution: School of Biological Sciences, University of East Anglia
Conclusion
The authors question the validity of the HTE-1 enhancer sequence's location within the TIMP-1 gene based on genomic analysis.
Supporting Evidence
- The HTE-1 enhancer element is claimed to be in the TIMP-1 gene but does not match genomic sequences.
- The best match for HTE-1 is found outside of the TIMP-2 gene on chromosome 17.
- The HTE-1 sequence is fully matched in the E. coli genome.
Takeaway
The researchers are unsure if a specific DNA sequence is really part of a gene because it matches a sequence found in bacteria instead.
Digital Object Identifier (DOI)
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