Allelotype influence at glutathione S-transferase M1 locus on breast cancer susceptibility
1999
Influence of GSTM1 Gene on Breast Cancer Risk
Sample size: 798
publication
Evidence: moderate
Author Information
Author(s): Charrier J, Maugard C M, Mevel B Le, Bignon Y J
Primary Institution: Unité d'Oncologie Génétique Moléculaire, Centre René Gauducheau, CRLCC Nantes-Atlantique, France
Hypothesis
Does the GSTM1 gene polymorphism influence breast cancer susceptibility?
Conclusion
The GSTM1 null genotype may increase the risk of post-menopausal breast cancer, particularly in women over 50.
Supporting Evidence
- The study involved 437 female controls and 361 breast cancer patients.
- The GSTM1 null genotype was more frequent in cancer patients.
- Breast cancer risk was increased in null subjects aged 50 and older.
Takeaway
This study looked at a gene that might affect the chances of getting breast cancer, especially in older women.
Methodology
The study assessed GSTM1 polymorphisms in 437 female controls and 361 breast cancer patients.
Participant Demographics
437 female controls and 361 community breast cancer patients from the west of France.
Statistical Information
P-Value
0.009
Confidence Interval
1.19–3.32
Statistical Significance
p=0.009
Digital Object Identifier (DOI)
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