Strength of Healing in Mouse Abdominal Incisions
Author Information
Author(s): Carlson Mark A., Chakkalakal Dennis, Lin Samuel J.
Primary Institution: University of Nebraska Medical Center
Hypothesis
What is the kinetics of strength gain in the ventral vertical midline incision in mice?
Conclusion
After 120 days of healing, the strength of the ventral vertical midline incision in mice was similar to that of nonwounded controls.
Supporting Evidence
- The incision attained 50% of its final strength by postoperative day 40.
- The maximal tension of the ventral vertical midline incision was nearly that of unwounded abdominal wall by postwounding day 60.
- There was no difference in unwounded vs. wounded maximal tension at postwounding day 120.
Takeaway
This study looked at how strong a cut in a mouse's belly gets over time, finding that it gets about half as strong after six weeks and is similar to normal tissue after 120 days.
Methodology
The study used a murine model to measure the tensile strength of abdominal wall incisions over time.
Limitations
The study was limited to a murine model, which may not fully represent human healing.
Participant Demographics
C57BL/6J male mice, 12 weeks old at time of wounding.
Statistical Information
P-Value
p=0.053
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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