Clinical Characteristics and Detection of MYB-QKI Fusions in Angiocentric Glioma Patients
Author Information
Author(s): Li Tiemin, Aihemaitiniyazi Adilijiang, Zhang Huawei, Wei Da, Hu Yue, Guan Yuguang, Zhou Jian, Qi Xueling, Wang Mengyang, Wu Bin, Zhu Mingwang, Zhang Linpeng, Luan Guoming, Liu Changqing
Primary Institution: Beijing Sanbo Brain Hospital, Capital Medical University
Hypothesis
What are the clinical characteristics and long-term prognosis of angiocentric glioma, and can MYB-QKI fusions be detected in these patients?
Conclusion
Angiocentric glioma is a rare benign tumor with a favorable prognosis after complete resection, characterized by refractory epilepsy and frequently occurring in adolescents.
Supporting Evidence
- 85.7% of patients were found to have MYB-QKI fusions.
- Most patients presented with drug-resistant epilepsy.
- Complete surgical resection typically leads to a satisfactory prognosis.
Takeaway
Angiocentric glioma is a rare brain tumor that often causes seizures in young people, but it can usually be treated successfully with surgery.
Methodology
Clinical, imaging, and pathologic data were collected from 14 patients diagnosed with angiocentric glioma at Beijing Sanbo Brain Hospital between March 2009 and March 2023.
Limitations
The study is limited by the small sample size and the rarity of angiocentric glioma cases.
Participant Demographics
The median age of participants was 16.5 years, with a range from 4 to 58 years; 9 were male and 5 were female.
Digital Object Identifier (DOI)
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