Antitumour Responses to Flavone-8-Acetic Acid and 5,6-Dimethylxanthenone-4-Acetic Acid in Immune Deficient Mice
Author Information
Author(s): L.-M. Ching, W.R. Joseph, B.C. Baguley
Primary Institution: Cancer Research Laboratory, Auckland University Medical School, Auckland, New Zealand
Hypothesis
Can flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid induce antitumour responses in T-cell deficient mice?
Conclusion
Flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid can induce growth delays and cures of Colon 38 adenocarcinoma in T-cell depleted mice through T-cell independent mechanisms.
Supporting Evidence
- 5,6-MeXAA has improved antitumour activity and higher potency compared to FAA.
- Both FAA and 5,6-MeXAA induce the synthesis of tumor necrosis factor.
- Growth delays and cures were observed in T-cell depleted mice treated with these agents.
Takeaway
Some medicines can help fight tumors even if the body's T-cells, which usually help fight infections, are not working.
Methodology
The study involved administering flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid to T-cell deficient mice with Colon 38 tumors and measuring tumor growth delays and cures.
Limitations
The study was limited by the number of animals used and the specific tumor model.
Participant Demographics
The study used T-cell deficient mice, specifically nude and thymectomised mice.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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