Contribution of glutamatergic projections to neurons in the nonhuman primate lateral substantia nigra pars reticulata for the reactive inhibition
2024
How Neurons in the Primate Brain Control Actions
Sample size: 3
publication
Evidence: moderate
Author Information
Author(s): Yoshida Atsushi, Hikosaka Okihide
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
Do individual SNr neurons in macaque monkeys modulate their activity to facilitate and suppress actions?
Conclusion
Glutamatergic inputs to the lateral SNr are crucial for action suppression in primates.
Supporting Evidence
- SNr neurons decreased firing rates during target selection and increased firing rates during rejection.
- Pharmacological blockade of glutamatergic inputs disrupted saccadic control.
Takeaway
This study shows that certain brain cells help us decide when to act and when to hold back, and they need special signals to do this.
Methodology
Monkeys performed a sequential choice task while their SNr neuron activity was recorded and manipulated.
Participant Demographics
Three male macaque monkeys.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website