Pulmonary Infections in a Dermatomyositis Patient
Author Information
Author(s): Maaya Fukumura, Ryosuke Hiwa, Satomi Yukawa, Yasuhiro Tsuchido, Hajime Yoshifuji, Akio Morinobu
Primary Institution: Kyoto University
Hypothesis
Can concurrent pulmonary infections with Aspergillus fumigatus and Lomentospora prolificans occur in a patient with anti-MDA5 antibody-positive dermatomyositis?
Conclusion
The addition of terbinafine to voriconazole treatment led to clinical improvement in the patient.
Supporting Evidence
- The patient was treated with immunosuppressive therapy for dermatomyositis.
- Voriconazole was initially used to treat Aspergillus fumigatus infection.
- Terbinafine was added due to suspected voriconazole resistance in Lomentospora prolificans.
Takeaway
A woman with a specific type of muscle disease got two lung infections at the same time, but doctors found a way to help her get better by using two different medicines together.
Methodology
The patient was treated with a combination of voriconazole and terbinafine after identifying the fungal infections through cultures and imaging.
Limitations
The drug susceptibility testing for the combined use of voriconazole and terbinafine could not be performed.
Participant Demographics
59-year-old female with anti-MDA5 antibody-positive dermatomyositis.
Digital Object Identifier (DOI)
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