Effects of Nicotinamide and Carbogen on Tumor Oxygenation and Blood Flow
Author Information
Author(s): Robinson S P, Howe F A, Stubbs M, Griffiths J R
Primary Institution: CRC Biomedical Magnetic Resonance Research Group, Division of Biochemistry, St. George's Hospital Medical School
Hypothesis
Nicotinamide and carbogen breathing enhance tumor radiotherapeutic response.
Conclusion
Both nicotinamide and carbogen significantly increased blood glucose levels and affected tumor energetics, but their combination did not show added effectiveness over carbogen alone.
Supporting Evidence
- Carbogen breathing showed large signal intensity increases in MRI.
- Nicotinamide induced a small increase in blood oxygenation.
- Both treatments caused significant increases in the βNTP/P i ratio.
- Blood glucose levels doubled with both nicotinamide and carbogen.
Takeaway
This study looked at how two treatments, nicotinamide and carbogen, affect tumors. They found that both treatments increased blood sugar in tumors, which might help with cancer treatment.
Methodology
Non-invasive MRI and 31P MRS methods were used to study the effects of nicotinamide and carbogen on transplanted rat GH3 prolactinomas.
Digital Object Identifier (DOI)
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